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Abstract: Primary non-Hodgkin’s lymphoma of bone (PLB) represents 5% of extranodal lymphoma manifestations and 7% of all bone lymphomas and is considered a rare clinical condition. Its manifestation is predominant in long bones, such as femur and pelvis (50%), and less frequently can affect the vertebral column (1,7%), with or without lymph node dissemination. In this case, we report a 55-year-old male patient with primary diffuse large B-cell non-Hodgkin's lymphoma (DLBCL), affecting the vertebral body of L4, with marked reduction of the vertebral canal and neuroforamina.